Changes in antioxidant enzyme levels and DNA damage during aging
نویسندگان
چکیده
منابع مشابه
Changes in DNA repair during aging
DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved ela...
متن کاملAntioxidant enzyme levels in cancer.
Normal cells are protected by antioxidant enzymes from the toxic effects of high concentrations of reactive oxygen species generated during cellular metabolism. Even though cancer cells generate reactive oxygen species, it has been demonstrated biochemically that antioxidant enzyme levels are low in most animal and human cancers. However, a few cancer types have been found to have elevated leve...
متن کاملSURVEY AND SUMMARY Changes in DNA repair during aging
DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved ela...
متن کاملExpression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens
PURPOSE To determine if there is increased mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage with age in the lenses of rats. We also explored the immunolocalization of 8-oxoguanine DNA glycosylase 1 (OGG1) and AP endonuclease 1 (APE1) in the lens and studied three of the predominant base excision repair (BER) enzymes: OGG1, APE1, and DNA polymerase gamma (Polgamma). METHODS The methods ...
متن کاملAlternation in Erythrocyte Enzyme Antioxidant Activity during Blood Storage
Background: Blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. Many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. Consequently, damage to erythrocytes by free radicals may occur. So it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days o...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 1998
ISSN: 0970-1915,0974-0422
DOI: 10.1007/bf02873438